Caffeine Consumption: What Science Tells Us
  Caffeine Consumption: What Science Tells Us Caffeine is the most widely used psychoactive substance globally. It’s found in coffee, tea, chocolate, energy drinks, some sodas, and even certain medications. While many of us consume it daily for alertness or enjoyment, its effects are complex and vary greatly depending on dose, individual sensitivity, timing, genetics, and other factors.   How Caffeine Works    Mechanism of action : Caffeine primarily acts by blocking adenosine receptors (especially A1 and A2A) in the brain. Adenosine is a neuromodulator that promotes sleep and relaxation; when its effects are inhibited, alertness increases and feelings of tiredness are reduced.    Metabolism : The liver, via cytochrome P450 enzymes (especially CYP1A2), is responsible for metabolizing caffeine. Genetic variations in these enzymes mean that people differ in how quickly they clear caffeine. Slow metabolizers are more likely to experience prolonged effects.  Potential Benefits of ...